ScienCell's GeneQuery™ Human PD-1/PD-L1 Checkpoint Pathway qPCR Array Kit (GQH-PDI) is designed to facilitate gene expression profiling of 88 key genes involved in human PD-1/PD-L1 checkpoint pathway, and to help identifying potential prognostic biomarkers for cancer immunotherapy. PD-1/PD-L1 checkpoint pathway plays an important role in the maintenance of T cell stability, as well as mediating inhibitory signals for proliferation and function of T effector cells. PD-1/PD-L1 immune checkpoint blockade has resulted in enhancement of T cell immunity against tumors and viral pathogens. Brief examples of how genes may be grouped according to their functions are shown below:
- Co-stimulatory/inhibitory receptors: PDCD1 (PD-1), CD28, CD27, CD276, ICOS, TNFRSF18, TNFRSF4, TNFRSF9
- Co-stimulatory/inhibitory pathway: CD274 (PD-L1), PDCD1LG2 (PD-L2), CD4, LCK, CD2, CD247, CSK, PTPN11, PTPN2, PTPN6, NCOR2
- PD-L1 induction: IFNG, IL15, IL17A, IL2, IL21, IL7, MAPK1, NRP1, STAT3
- T cell receptor signaling: AKT1, CD3, CTLA4, CD8, GSK3B, JUN, NFKB1, PDPK1
- T cell function regulation: BATF, FOXO1, KRAS, MAPK8, MTOR, NFATC1, PI3Ks, SKP2, TLR9
- B cell function regulation: CD80, CD86, POU2F2
- Proinflammatory molecules: CSF2, IL4, IL10, IRF6, TNF, VEGFA
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Additional immune checkpoint genes:HAVCR2, HNF1A, LAG3, TIGIT
Note: all gene names follow their official symbols by the Human Genome Organization Gene Nomenclature Committee (HGNC).
货号 | GK121 |
产地 | 美国 |
缩写 | GQH-PDI |
规格 | One 96-well plate, one 20ul reaction per well |
用途 | 科研 |
储存 | 4°C |
运输 | 胶冰 |
货号 | 产品名称 | 规格 | 价格 | 指令 | |
GK040 | 人成纤维细胞生长因子信号通路qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK041 | 人体皮肤伤口愈合qPCR检测套件 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK056 | 人体止血qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK060 | 人类昼夜节律qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK061 | 人类DNA损伤感应qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK062 | 人类细胞生长和分裂qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK063 | 人细胞周期蛋白和细胞周期蛋白依赖性激酶qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK069 | 人类小胶质细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK072 | 人类适应性免疫反应qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK073 | 人类小胶质细胞Sensome qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK074 | 人角质细胞生物学qPCR检测 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK078 | 人类神经细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK079 | 人类软骨细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK080 | 人成骨分化qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK081 | 人类周细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK084 | 人体轴突导向qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK087 | 人类染色质组织和重塑qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK088 | 人VEGF信号通路qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK089 | 人类Ephrin信号qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK090 | 人体细胞连接qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK091 | 人肝星状细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK092 | 人胰腺星状细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK093 | Human Renal Mesangial Cell Biology qPCR Array Kit | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK094 | Human Mesenchymal Stem Cell Differentiation qPCR Array | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK095 | 人间充质至上皮细胞转化qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK096 | 人类雪旺细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK097 | 人类平滑肌细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK098 | 人类心脏肌细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK099 | 人类骨骼肌细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + | |
GK100 | 人角质形成细胞生物学qPCR检测试剂盒 | One 96-well plate, one 20ul reaction per well | $286 | + |